EFFECT OF MARSHAL (CARBOSULFAN,METHYL CARBAMATE) ON REPRODUCTIVE SYSTEM AND THYROID GLAND OF MALE RATS

Authors

1 Department of Physiology, Fac. Vet. Med., Cairo University

2 Dept. of Pharmacology, Animal Health Research institute, Cairo

Abstract

Oral administration of Marshal (carbosulfan, methyl carbamate) in doses of 4.20 and 10.50mg/kg b.wt. daily for 65 successive days significantly increased the weight of testes and decreased the weight of prostates and epididymes. Epididymal sperm characters including sperm motility and concentration were reduced, while the sperm abnormalities were increased. Moreover, the activity of testicular enzymes lactate dehydrogenase (LDH), alkaline Phosphatase (ALP), and gamma-giutamy1 transferase (GGT) were increased, while the activity of acid phosphatase was decreased. Marshal increased the weight of thyroid glands and the Plasma level of thyroid stimulating hormone (TSH), while triiodothyronine (T3) and thyroxine (T4) were reduced. Regarding some biochemical parameters, Marshal decreased the blood Glucose level and reduced the plasma activities of  aspartate amino-transferase (AST) and alanine amino-transferase (ALT), while total cholesterol was increased. Moreover, Marshal induced histopathological alterations in testes and livers. Thus, Marshal has been shown to induce marked structural and functional changes in reproductive system and thyroid glands of male rats.

Main Subjects

Veterinary Medical Journal (Giza)
Volume 46, Issue 4
October 1998
Pages 809-819

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