INFLUENCE OF IVERMECTIN ON THE PHARMACOKINETICS OF DOXYCYCLINE IN RABBITS

Authors

pharmacology Department, Faculty of Veterinary Medicine, Cairo University Giza - 12211

Abstract

The pharmacokinetic aspects of doxycycline were studied in normal and ivermectin-medicated rabbits after a single intravenous and oral administrations of 20 mg ke-1b.wt. Plasma concentrations of doxycycline were determined by microbiological assay . After intravenous injection, the plasma concentration-time curve of doxycycline was characteristic of  a two-compartment open model with a rapid distribution phase and slower elimination phase. The elimination half-lives (t1/28) were 7.98 and 6.19 hours and the mean residence times (MRT) were 11.15 and 8.61 hours in normal and ivermectin-medicated rabbits , respectively. The Volume of distribution and the total clearance values Were quite similar in both groups. Following Oral administration , doxycycline was rapidly absorbed in normal and ivermectin-medicated rabbits with absorption half-lives (t1/2 ab)of 33.85 and 28.81 minute, respectively .The peak plasma concentrations (Cmax) were 15.60 and 18.93 ug ml-1and were attained at (Tmax) 2.30 and 1.87 hours , respectively . The elimination half-life (t1/2 2el)of doxycycline after oral administration was shorter in pre-medicated rabbits than in normal ones. The systemic bioavailability percentages (F%) of doxycycline after oral administration were 88.63% and 90.64 % in normal and ivermectin medicated rabbits , respectively. The present study showed that if ivermectin is used concomitantly, altered doxycycline pharmacokinetics should be anticipated.

Main Subjects

Veterinary Medical Journal (Giza)
Volume 46, Issue 4
October 1998
Pages 797-807

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