EFFECT OF MALACHITE GREEN ON THE EFFICACY AND PHARMACOKINETICS OF OXYTETRACYCLINE WITH SPECIAL REFERANCE TO THEIR BIOCHEMICAL AND HORMONAL CHANGES IN EXPERIMENTALLY INFECTED CLARIAS LAZERA

Authors

1 Departments of Pharmacology, Faculty Of Veterinary Medicine; Cairo University; Giza 12211. Egypt

2 Departments of Physiology Faculty Of Veterinary Medicine; Cairo University; Giza 12211. Egypt

Abstract

The effect of malachite green on the efficacy, pharmacokinetics and tissue depletion of oxytetracycline was studied in Clarias lazera (catfish) experimentally infected with Aeromonas hydrophila . Infected fish were exposed to oxytetracycline (100 mg L-1) as a bath with or without malachite green ( 2 mgL-1) for 15 minutes daily for 7 consecutive days. The obtained results showed that malchite green augmented the efficacy of oxytetracycline by reducing the mortalities and enhanced its elimination from serum and tissue .The elimination half-life was (T1/2el) of 11.748± 0.52 hours and mean residual time(MRT) was of 17.337 + 0.88 hours. Residues of oxytetracycline were detected in muscles UP to 15 days after the cessation of treatment when it was given alone. While malachite green enhanced the residue depletion of oxytetracycline from muscles, as it could not be detected up to 10 days in fish treated with both agents. The combination of oxytetracycline and malachite green increased the gonadal secretion of sex steroids (either testosterone or 17-β estradiol) via elevation of gonadotropin (LH) levels in both sexes. The liver and kidney functions and glucose utilization were also improved in experimentally infected fish treated with both drugs rather than the use of oxytetracycline alone allover the withdrawal periods.

Main Subjects

Veterinary Medical Journal (Giza)
Volume 46, Issue 4
October 1998
Pages 555-567

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