THE THERAPEUTIC EFFICACY OF DORAMECTIN , IVERMECTIN AND LEVAMISOLE AGAINST DIFFERENT STAGES OF TRICHINELLA SPIRALIS INFECTION IN RATS

Authors

1 Pharmacology Departments, Faculty of Veterinary Medicine, Cairo university

2 Parasitology Departments, Faculty of Veterinary Medicine, Tante university

Abstract

In this study, 3 commonly used anthelmintics are tried in experimental Trichinella spiralis infection in an attempt to reach a successful treatment. Doramectin (0.2 mg/kg), ivermectin (0.2 mg/kg) and levamisole (7.5 mg/kg) were tested for their anthelmintic efficacies against experimental T. spiralis infection in rats. Animals were infected with 500 larvae and the drugs were tested against adult worms at 4th day, migrating larvae at 10th day and encysted larvae at 35th day post-infection. Rats were sacrificed, 5 days post treatment. Mature worms and migrating larvae counts were significantly reduced in doramectin and ivermectin medicated rats compared with non-treated controls. Levamisole was the least effective drug with 4.83 and 3.57 % efficacies against mature worms and migrating larvae, respectively. Doramectin showed the highest efficacy in eliminating both mature worms and migrating larvae of T. spiralis (97.75 and 86.23 % , respectively ) followed by ivermectin ( 94.99 and 83.85 %, respectively). The tested anus failed to attack the encysted larvae in the diaphragms of infected rats. Moreover, experimental infection of rats with spiralis, significantly reduced the values of total proteins and albumin while globulin, urea and creatinine values and the activities of AST and ALT were significantly increased. Doramectin and ivermectin induced an improvement in the previous parameters when given at 4th and 10th days post-infection but failed when injected at 35th day post-infection.

Main Subjects

Veterinary Medical Journal (Giza)
Volume 46, Issue 4
October 1998
Pages 527-541

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