Protective effects of date extract against toxic effects of lead acetate in rats

Authors

1 Graduate student, Faculty of Veterinary Medicine, Cairo University

2 Department of Microbiology, Faculty of Veterinary Medicine, Cairo University

3 Department of Veterinary Hygiene and Management, Faculty of Veterinary Medicine, Cairo University

4 Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University

Abstract

Lead (Pb) is a common industrial and environmental pollutant, Prolonged exposure of a sublethal dose to this toxicant is associated with oxidative stress and considered to be a risk factor for kidney and liver in addition to many disorders. This study was carried out to investigate the most toxic effects of lead with a trial to diminish this toxicity by supplementation: of date extract, Both the enzymatic {superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPx) glutathione-S-transferase (GSH-T) and catalase (CAT)}, and non- enzymatic (glutathione, GSH) antioxidants has been studied among mature male albino rats which have been received lead acetate in drinking water for 3 months. It is widely accepted that even small quantities of Pb are harmful to rats which is implicated in a broad range of physiological conditions. The study proved that the use of date extract, through its antioxidant protective effect and immune potentiating properties, can reduce Pb-induced hepatic damage and toxicity.

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