Synergetic Action of Dietary Nucleotides and Phytobiotics as Entero-Hepatic Tonic, Immune Modulators, and Growth Promoters in Broiler Chickens

Bastamy, Mustafa; Khedr, Nasser; Raheel, Ismail; Elbestawy, Ahmed; Abdel-Latif, Mervat; Orabi, Ahmed

doi:10.21608/vmjg.2025.406300.1049

Synergetic Action of Dietary Nucleotides and Phytobiotics as Entero-Hepatic Tonic, Immune Modulators, and Growth Promoters in Broiler Chickens

Document Type : Original Article

Authors

¹ Department of Poultry Diseases, Faculty of Veterinary Medicine, Cairo University

² Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Benha University

³ Department of Bacteriology, Mycology and Immunology, Faculty of Veterinary Medicine, Beni-Suef University

⁴ Department of Bird and Rabbit Diseases, Faculty of Veterinary Medicine, Menoufia University

⁵ Department of Nutrition and Veterinary Clinical Nutrition, Faculty of Veterinary Medicine, Damanhour University

⁶ Department of Microbiology, Faculty of Veterinary Medicine, Cairo University

10.21608/vmjg.2025.406300.1049

Abstract

The global poultry production industry is currently facing significant challenges due to the complete or gradual removal of in-feed antibiotics. One of the most impactful diseases under these conditions is necrotic enteritis (NE), which causes considerable economic losses by compromising intestinal wall permeability and liver health in broiler chickens. The present study investigates the efficiency of dietary nucleotides and phytobiotics feed supplementation on broiler intestinal to alleviate (NE and their effects on gut, liver, growth performance, and immunity parameters. Four groups (Gs) of broiler chickens were allocated as G1; nucleotides and phytobiotics from day one till the end of the experiment with a dose of 200 g and 250 g/ton feed, respectively and non-challenged with Clostridium perfringens (C. perfringens), G2; nucleotides and phytobiotics treated as G1 and challenged with C. perfringens, while respectively G3 and G4 were control non-treated, challenged and non-challenged groups, The results revealed that C. perfringens challenge in treated chickens had little effects on liver functions, growth performance, immunity parameters, and gut integrity genes (Occuldin, JAM, and MUC) which indicated the beneficial effects of continuous feed supplementation with nucleotides and phytobiotics in broilers.

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