EFFECTS OF CHRONIC ALUMINIUM ADMINSTRATION ON BRAIN AND LIVER ENZYME ACTIVITIES AND TRACE ELEMENTS CONENTRATION IN RATS WITH EVALATION OF THE PROTECTIVE ROLE OF VITAMIN A AND RIBOFLAVIN

Document Type : Original Article

Authors

1 Departments of Biochemistry, Faculty of Veterinary Medicine, Zagazig University/Benha Branch Mosshtohor, Toukh, EGYPT

2 Departments of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University/Benha Branch Mosshtohor, Toukh, EGYPT

3 Departments of Animal Medicine , Faculty of Veterinary Medicine, Zagazig University/Benha Branch Mosshtohor, Toukh, EGYPT

4 Departments of Physiology, Faculty of Veterinary Medicine, Zagazig University/Benha Branch Mosshtohor, Toukh, EGYPT

Abstract

Aluminum (AI) has been implicated in the pathogenesis of several clinical disorders such as dialysis dementia and Alzheimer’s diseases. This study investigates the effect of aluminum chloride on brain and liver function enzymes, contents of Fe, Cu, Zn and antioxidant enzymes activities in rats and the effect of riboflavin and vitamin A in alleviating such effects. Four equal groups of Sprague Dawleyy rats were used (n=10). Group 1: received AL (20 mg/ kg/ day) for 12 weeks. Group 2: received AI and vitamin A (30 IU/g). Group 3: received AI and riboflavin (15 mg/kg). Group 4: was control. Results showed that brain function enzymes were significantly decreased in AL-treated group. Al plus vitamin A or riboflavin alleviates this reduction. Concentration of Fe was significantly decreased in cerebral and hepatic homogenates in Al and Al plus vitamin A treated groups. Concentration of  Zn and Cu showed significant decrease in brain homogenates in AL treated group and non-significant decrease in AL plus vitamin A or riboflavin treated groups. The activities of antioxidant enzymes were significantly reduced in AL treated group. Al plus vitamin a or riboflavin improved these antioxidant activities. It is concluded that AL exposure induced significant changes in the hepatic and cerebral enzymatic activities, trace elements content and antioxidant activities. The incorporation of riboflavin or vitamin A improved hepatic and cerebral functions, suggesting their protective role in aluminum toxicity.

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Veterinary Medical Journal (Giza)
Volume 53, Issue 2
April 2005
Pages 423-437

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