COMPARATIVE EVALUATION OF THE IMMUNE EFFICACY FOR FMD VACCINES PREPARED WITH MONTANIDE ISA50 AND ALUMINUM HYDROXIDE GEL IN CATTLE

ALI, S; SAAD, M

doi:10.21608/vmjg.2005.384674

COMPARATIVE EVALUATION OF THE IMMUNE EFFICACY FOR FMD VACCINES PREPARED WITH MONTANIDE ISA50 AND ALUMINUM HYDROXIDE GEL IN CATTLE

Document Type : Original Article

Authors

S ALI ¹
M SAAD ²

¹ Foot and Mouth Disease Department, Veterinary Serum and Vaccine Research Institute,Abbasia, Cairo, Egypt, postal code.11381

² Central Laboratory for Control of Veterinary Biologics, Abbasia, Cairo, Egypt.

10.21608/vmjg.2005.384674

Abstract

Montanide ISA50 and Aluminum hydroxide gel were used as adjuvant for preparation of FMD vaccine. The vaccines were tested in Guinea pigs and cattle.Serum neutralization test and indirect ELISA were carried out to follow up the immune status of vaccinated cattle for 30 weeks post vaccination (WPV).The revealed results indicate that the vaccine emulsified with Montanide ISA50 adjuvant appeared to be more potent and gave a higher level of immunity to the vaccinated cattle than that produced from AL (OH) 3 gel vaccine till the end of the 30 (WPV). Also that indicates the ability of Montanide ISA50 oil adjuvant vaccine for serological responses toFMD antigens more than AL (OH) 3 gel adjuvant vaccine

Main Subjects