CYTOTOXIC EFFECTS OF THE PYRETHROID INSECTICIDE (MATOX)® WITH REFERENCE TO ITS INFLUENCE ON THE REPRODUCTIVE HORMONE

Document Type : Original Article

Authors

1 Pharmacology Dept, Fac. Vet. Med., Alex Univ, Egypt

2 Physiology Dept, Fac. Vet. Med., Alex Univ, Egypt

3 Genetics Dept, Fac. Vet. Med., Alex Univ, Egypt

4 Forensie Fac. Vet. Med., Alex Univ, Egypt

Abstract

Male rats exposed 10 the aerosols of the | pyrethroid insecticide (Matox)™ at a level of one Flet/36 m3 for 10 hours daily up 10 2,4 and 8 weeks revealed a significant decrease in weight of testis epididymis. seminal vesicle and prostate glands after 4 and 8 weeks. The sperm motility percentage was significantly decreased after 2,4 and 8 weeks of exposure to Matox aerosols while the sperm cell concentration was significantly decreased after 4 and 8 weeks of exposure to Matox aerosols.
Male rats exposed to Matox aerosols showed a significant decrease in the level of LH and  testosterone hormone after 4 and 8 weeks. Meanwhile, the FSH level was reduced only after 8 weeks of exposure. 
Cytogenetic studies revealed that Matox have either visible effect on chromosomes structure  and arrangement nor numerical chromosomal aberrations. However, the miotic division of testicular cells in Matox treated group were highly significantly decreased when compared with  of control one.
Hematological studies showed that Matox aerosols induced a significant decrease in R.B.Cs.  and W.B.C counts, Hb content and PCV after 2,4 and 8 weeks.

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