Effect of long term (180 days) treatment with different concentrations of lead nitrate (0.25, 0.5, 0.75 and 1.0 mg/kg/day) dissolved in drinking water was studied on male adult white mice Mus musculus. All the concentrations used caused decrease in the body weight of the animals. This decrease was more noticeable in the higher concentrations. Also both the daily body weight gain and the daily food intake was affected. Introducing of Iead in the drinking water resulted in different percentages of mortality at the end of the exposure period. Mortality percentages were 20, 20 and 27% for the concentrations 0.5, 0.75 and 1.0 mg/kg/day, respectively. The organ weight/total body weight ratio of the treated mice was affected. the ratio either decreased or increased in contrast to control. The maximum ratio observed in the case of liver and kidney weights were 103 and 109% in mice exposed to 1.0mg/kg/day lead, respectively. A gradual inhibition which correlated with lead concentration was observed in the cholinesterase (ChE) activity of all the tested organs (liver, brain, kidney and plasma). Lead has been shown signs of toxicity included ataxia, diarrhea and hypertension. The data indicated that the enzyme activity of acid phosphatase (Acp), alkaline phosphatase (Ap) and lactic acid dehydrogenase (LDH) of the different organs of the lead treated animals was affected as compared with control.
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