TESTING A NEW FORMULATION OF IVERMECTIN (IVOMEC POUR-ON & BOLUS) AS BROAD SPECTRUM PARASITICIDE

ABDEL-RAHMAN, M.; EL-BAHY, M.; EL-BAITY, N.; RAMADAN, E.

doi:10.21608/vmjg.1996.376629

TESTING A NEW FORMULATION OF IVERMECTIN (IVOMEC POUR-ON & BOLUS) AS BROAD SPECTRUM PARASITICIDE

Document Type : Original Article

Authors

¹ Department of Parasitology, Faculty of veterinary Medicine, Cairo University ‘

² Department of Parasitology, Faculty of Veterinary Medicine, Tanta University

³ Department of Parasitology, Faculty of Veterinary Medicine, Tanta University .

10.21608/vmjg.1996.376629

Abstract

Two new formulations of ivermectin (MSD AGVET), Ivomec pour-on used for cattle in a dose of 1ml/10kg.b.w. and Ivomec bolus used per mouth for sheep in a dose of 1/2 bolus for each 25kg.b.w. (10 mg/50 kg.b.w.), were tested for control of natural infestation by gastrointestinal nematode parasites (G.I.N.) in cattle and sheep as well as for treatment of mange infection in sheep
The two drugs showed promising results in the form of freeing the treated animals from the target parasites by a percentage varies from 60-100% (in a mean of 85%) and decrease in the mean eps/gram feces (EPGF) from 695 on day zero to 15 EPGF on 35th day post-treatment (d.p.t.) for the pour-on form and 80-100% in sheep G.I.N. with marked decrease in the mean total EPGF from 756 on day zero to 8.3 EPGF in 28th d.p.t.
The bolus form succeeded in eradication of mange from the treated sheep by an efficacy varying from 82.69-100%. The two drugs showed absolute protection for the treated animals till 21st d.p.t. and very marked decrease in EPGF even for the still positive animals till end of the observation period. Cooperia, Nematodierus and Trichuris species appear slightly less susceptible to the used dose of the drugs than the other gastrointestinal nematode larvae.
Concerning the pour-on form, the drug was easily administered, safe for the administrator, rapidly absorbed and did not show any post administration reaction while the bolus form needs some precautions during administration.
It is worthy to mention that changing the mode of IVOMEC administration from injection to topical or swallowing way did not reflect the previous successful market known results of Ivomec injection, but it improved the drug application and use without decreasing its parasiticidal efficacy.

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