THE EFFECT OF DIFFERENT NEUROTRANSMITTERS ON-SOME HORMONAL PROFILE OF IMMATURE FEMALE RATS

Document Type : Original Article

Authors

Physiology Dept. Fac. Vet. Med., Cairo University

Abstract

 
The first objective of the present investigation was to evaluate the relative contributions of the ovarian steroid in the feed back limb of the ovarian pituitary axis. The second was to test the ability of morphine or L-Dopa or both in modulating PRL, PROG, FSH and LH levels noticed in female rats previously treated with estrogen during prepubertal period.
Forty immature female rats were divided into five equal groups and exposed to different (treatment. Control olive oil; estrogen; and M. S.; estrogen and L- Dopa; and estrogen, M. S. and- L-Dopa. Animals were inspected daily for vaginal opening and estrous. manifestation. Blood samples were collected at the end of experimental period and” estimated by Radioimmunoassay kits for PRL, LH, FSH and PROG.
The data obtained revealed that sexual precocity elicited either with estrogen or estrogen +: L-Dopa treatment of the neurotransmitter in hypothalamic sensitivity to estrogen in induction of puberty maybe considered.

Main Subjects