KINETIC DISPOSITION, SYSTEMIC BIOAVAILABILITY AND TISSUE DISTRIBUTION OF APRAMYCIN IN BROILER CHICKENS

A., AFIFI; A., RAMADAN

doi:10.21608/vmjg.1996.376604

KINETIC DISPOSITION, SYSTEMIC BIOAVAILABILITY AND TISSUE DISTRIBUTION OF APRAMYCIN IN BROILER CHICKENS

Document Type : Original Article

Authors

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, P.O. Box12211, Egypt.

10.21608/vmjg.1996.376604

Abstract

Apramycin was administered to chickens orally, intramuscularly and intravenous to determine blood concentration, kinetic behaviour, bioaviability and tissue residues. The drug was given through intracrop, i.m. and i.v. routes in a single dose of 75 mg kg-1 body weight. The highest serum concentrations of apramycin were reached 0.20 and 0.76 hours after a single oral i1.m. dosage with an absorption half-life [t 1\2 (ab)] 0.10 and 0.19 hours and elimination half-life [t 1\2 β)}1.21 and 0.53 hours, respectively. The systemic bioavailability percentage 2.03 and 57.96 percent after intracrop and i.m. administration, respectively, indicating the very lower extent of apramycin absorption from the oral route in chickens. Following i.v. injection, the kinetic of apramycin can be described by a two-compartment open model with a ( t 1\2 (α) 1.5 hours, (volume of distribution) Vd(ss) was 4.82 litre kg"! and CI(B) (total body clearance) was 1.88 litre k -1 h -1. The serum protein-binding ‘tendency of apramycin as calculated in vitro was 26 percent.
The highest concentration of apramycin residues were present in the kidneys and liver after a successive daily intracrop and i.m. administration for 5 days. No apramycin residues were detected in tissues after 6 hours except in the liver and kidneys and that disappeared completely by 12 and 24 hours after intracrop and i.m administration, respectively

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