Pefloxacin (PEL) was administered intravenous-ly (iv) and intramuscularly (im) at a dose rate of ‘Omg kg"! b.wt. to five healthy,weighing 18-22 kg. Blood, urine lactating goats and milk samPles Were collected at precise time intervals and ne “oncentrations were determined by using a microbiological assay method. The pharmacoki- parameter Were estimated using routine equation. A two Compartment Open model best described the decrease of pefloxacin concentration in serum after intravenous injection. The drug was rapidly and widely distributed with distribution half life (tla of 0.097 + 0.012 h and steady state volume of distribution (Vdss) 5.144 +0.206 L kg. PEL was rapidly absorbed after im injection with an absorbtion halflife of 0.315+0.016 h. the peak serum concentration Cmax was 0.862+ 0.083 mg.ml at T max 0.75 h. the systemic bioavailability after im injection was 70.632+1.130% and the serum protien bound fraction was 9.756+ 1.573%. the drug was detected in milk and urine for 12 and 72 h, respectinely.
ABD EL-ATY, A., & GOUDAH, A. (2000). PHARM ACOKINETIC BEHAVIOR OF PEFLOXACIN IN LACTATING GOAT. Veterinary Medical Journal (Giza), 48(4), 467-477. doi: 10.21608/vmjg.2000.376558
MLA
A ABD EL-ATY; A GOUDAH. "PHARM ACOKINETIC BEHAVIOR OF PEFLOXACIN IN LACTATING GOAT", Veterinary Medical Journal (Giza), 48, 4, 2000, 467-477. doi: 10.21608/vmjg.2000.376558
HARVARD
ABD EL-ATY, A., GOUDAH, A. (2000). 'PHARM ACOKINETIC BEHAVIOR OF PEFLOXACIN IN LACTATING GOAT', Veterinary Medical Journal (Giza), 48(4), pp. 467-477. doi: 10.21608/vmjg.2000.376558
VANCOUVER
ABD EL-ATY, A., GOUDAH, A. PHARM ACOKINETIC BEHAVIOR OF PEFLOXACIN IN LACTATING GOAT. Veterinary Medical Journal (Giza), 2000; 48(4): 467-477. doi: 10.21608/vmjg.2000.376558
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