The pharmacokinetic profile, tissue distribution and residual content of pipemidic acid were studied in normal and nephritic rats. The maximum serum concentration was reached after 1 hr. in both normal and nephritic rats following oral administration of 50 mg/kg b. wt. Lower serum concentrations were detected in nephritic rats at corresponding time intervals as compared with healthy ones. Following. The intravenous injection of pipemidic acid, the resulting curves were best fitted to follow two compartment open model. The drug was highly. distributed in all tested tissues and completely disappeared from all tissues after 9 and 15 days in healthy and nephritic rats following its oral administration in a dose of 50 mg/kg b. wt. twice daily for 5 successive days.
ABD EL-ATY, A., GOUDAH, A., M., A., M., A., A., E. B., & A., S. (1996). PHARMACOKINETIC PROFILE OF PIPEMIDIC ACID INNORMAL AND NEPHRITIC RATS. Veterinary Medical Journal (Giza), 44(2), 453-461. doi: 10.21608/vmjg.1996.376557
MLA
A ABD EL-ATY; A GOUDAH; ATEF M.; AMER M.; El- BANNA A.; SOLIMAN A.. "PHARMACOKINETIC PROFILE OF PIPEMIDIC ACID INNORMAL AND NEPHRITIC RATS". Veterinary Medical Journal (Giza), 44, 2, 1996, 453-461. doi: 10.21608/vmjg.1996.376557
HARVARD
ABD EL-ATY, A., GOUDAH, A., M., A., M., A., A., E. B., A., S. (1996). 'PHARMACOKINETIC PROFILE OF PIPEMIDIC ACID INNORMAL AND NEPHRITIC RATS', Veterinary Medical Journal (Giza), 44(2), pp. 453-461. doi: 10.21608/vmjg.1996.376557
VANCOUVER
ABD EL-ATY, A., GOUDAH, A., M., A., M., A., A., E. B., A., S. PHARMACOKINETIC PROFILE OF PIPEMIDIC ACID INNORMAL AND NEPHRITIC RATS. Veterinary Medical Journal (Giza), 1996; 44(2): 453-461. doi: 10.21608/vmjg.1996.376557
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