EFFECT OF SYNANTHIC AND IVOMEC ON TRICHINELLA SPIRALIS WITH REFERENCE TO THEIR SEROLOGICAL EVALUATION

Document Type : Original Article

Authors

1 Dept. Parasitology

2 Dept. Parasitology, Animal Health Research Inst. Dokki, Giza

3 Dept. Pharmacology, Fac. Vet. Med., Cairo University

4 Dept. Bacteriology, Immunology and Mycology, Fac. Vet. Med., Cairo

Abstract

Three groups, each of 10 rats were experimentally infected with Trichinella spiralis larvae (250/rat). On the 5th week postinfection animals of two groups were treated with a single dose of Synanthic (Oxfendazole) and Ivomec MK-933 at a dose of 5 mg and 0.2 mg/kg B. W. respectively. Efficacy rate of the former was 84.2% and for the later was 73.5% depending on the number of living larvae in the diaphragm. Anti-Trichinella spiralis haemagglutinating antibodies were monitored before and after treatment. They were markedly declined two weeks after treatment. This makes passive haemagglutination test a feasible test to evaluate the drug efficacies either in laboratory or field studies.

Main Subjects

Veterinary Medical Journal (Giza)
Volume 43, Issue 1
January 1995
Pages 31-35

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