LIVER AND KIDNEY FUNCTIONS IN CATTLE VACCINATED WITH TISSUE CULTURE RINDERPEST VACCINE

Document Type : Original Article

Authors

1 Rinderpest Vaccine Department. Serum and Vaccine Research Institute, Abbassia, Cairo.

2 Department of Physiology. Fac. Vet. Med. Cairo University.

Abstract

This study was conducted to determine the effect of rinderpest tissue culture vaccine on the hepato-renal functions of cross-breed Friesian calves. Eight claves 8-14 months of age and weighing 150-180 Kg were vaccinated with tissue culture rinderpest vaccine (104 TCID50 / ml / calf). and blood samples were collected before vaccination and at 3,7,14 ad 21 days post-vaccination. The results revealed that the calves became immunized against rinderpest disease where the neutralizing antibodies reach tis peak (2.52 + 0.02 logl0 / ml) by 21 days. The calves showed increase in total protein at 21 days and globulin at 14 and 2] days, while albumin was decreased at 14 and 21 days. SGOT, SGPT, bilirubin, creatinine and blood-urea-nitrogen did not change. It is concluded that the tissue culture rinderpest vaccine has no effect on liver and kidney functions and produce a good level of immunity.

Main Subjects