In the present study, the effect of the antibiotic, norfloxacin on the bile flow was investigated in anaesthetized guinea pigs. Intramuscular administration of the drug in a dose of 5 mg/kg body weight resulted in a 28% decrease in the bile flow. The cholestatic effect of norfloxacin was not counteracted by administration of the choleric drug, clanobutin sodium. Meanwhile administration of caffeine citrate significantly counteracted the cholestatic effect of norfloxacin. Moreover, norfloxacin has an inhibitoryeffect on the motility of isolated rabbit duodenum and induced relaxation of the isolated guinea pig ilium.
FAYED, E., MOHAMED, M., & ABDEL AZEEZ, A. (1994). EFFECT OF THE ANTIBIOTIC, NORFLOXACIN ON BILE FLOW IN GUINEA PIGS. Veterinary Medical Journal (Giza), 42(2), 9-14. doi: 10.21608/vmjg.1994.371664
MLA
EL-ASHMAWY FAYED; M MOHAMED; A ABDEL AZEEZ. "EFFECT OF THE ANTIBIOTIC, NORFLOXACIN ON BILE FLOW IN GUINEA PIGS", Veterinary Medical Journal (Giza), 42, 2, 1994, 9-14. doi: 10.21608/vmjg.1994.371664
HARVARD
FAYED, E., MOHAMED, M., ABDEL AZEEZ, A. (1994). 'EFFECT OF THE ANTIBIOTIC, NORFLOXACIN ON BILE FLOW IN GUINEA PIGS', Veterinary Medical Journal (Giza), 42(2), pp. 9-14. doi: 10.21608/vmjg.1994.371664
VANCOUVER
FAYED, E., MOHAMED, M., ABDEL AZEEZ, A. EFFECT OF THE ANTIBIOTIC, NORFLOXACIN ON BILE FLOW IN GUINEA PIGS. Veterinary Medical Journal (Giza), 1994; 42(2): 9-14. doi: 10.21608/vmjg.1994.371664
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