SUCCESSFUL REVERSAL OF HYPERGLYCAEMIA IN DOGS WITHOUT IMMUNOSUPPRESSION

MAHGOUB, M; AMMAR, A; KHAMIS, Y; SHETA, E; ABDEI AZIZ, H; EDRIS, A

doi:10.21608/vmjg.2002.369364

SUCCESSFUL REVERSAL OF HYPERGLYCAEMIA IN DOGS WITHOUT IMMUNOSUPPRESSION

Document Type : Original Article

Authors

¹ Islet Transplantation Research Center, Ain Shams University Hospital and Department of Surgery, Anaesthesiology and Radiology

² Islet Transplantation Research Center, Ain Shams University Hospital and Department of Surgery, Anaesthesiology and Radiology.

³ Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt

10.21608/vmjg.2002.369364

Abstract

A natural macro-capsule consisted of a full-term pregnant bitch’s amniotic membrane and pre- served porcine pancreatic islets of Langerhans was implanted intra-abdominally either in the omental pouch (group 1, n=6) or freely in the peritoneum (group 2, n=4) of alloxan induced dia- betic mongrel dogs. This macro-capsule constituted a biocompatible and permi-selective immune barrier containing purified porcine islets. It was able to reverse hyperglycemia in the diabetic dogs and did not lead to the hazards of artificial devices such as interstitial acute and chronic inflamma- tory reactions, development of granulation tissue and intestinal adhesions. Moreover, revascularizaTion of this natural membrane prolonged the survi- val and viability of islets.

Main Subjects