Teratogenic effects of abamectin in rats

H, Zaghloul; S, El-Ballal; M, Morgan; E, El Bialy

doi:10.21608/vmjg.2011.368352

Teratogenic effects of abamectin in rats

Document Type : Original Article

Authors

¹ Theriogenology, Departments, Faculty of Veterinary Medicine, Minufiya University, El-Sadat city branch, Egypt

² Pathology, Departments, Faculty of Veterinary Medicine, Minufiya University, El-Sadat city branch, Egypt

³ toxicology and Forensic Medicine Department, Faculty of Veterinary Medicine, Cairo University, Egypt

⁴ Forensic Medicine and Toxicology, Departments, Faculty of Veterinary Medicine, Minufiya University, El-Sadat city branch, Egypt

10.21608/vmjg.2011.368352

Abstract

The teratogenic effects of abamectin pesticide on pregnant rats were studied following oral administration of 2.85, 1.42 and 0.72 mg/ kg bw (1/10, 1/20 and 1/40 of the oral LD50, respectively) during the organogenesis period. Treatment with abamectin did not influence the reproductive status (number of uterine implants, resorptions, live and dead fetuses per litter) at all dosage levels. However, it caused significant increase in the percentages of morphological, visceral and skeletal malformations in rat fetuses on exposure to the two high doses compared to control. In addition , abamectin induced different pathological alterations in the placentae and fetal organs in a dose-related manner.

Keywords