The use of Swiss mice in comparison with the specific host for the evaluation of live attenuated Salmonella Typhimurium and Salmonella Enteritidis vaccine for chicken

Document Type : Original Article

Authors

Central Laboratory for Evaluation of Veterinary Biologics (CLEVB).

Abstract

  In this study, a total of 600 SPF chicks and 1200 Swiss mice were used to compare between both in the evaluation of live Salmonella Enteritidis and Salmonella Typhimurium vaccines. Results revealed that, 81% and 78% protection were obtained after vaccination and challenge with Salmonella Enteritidis and Salmonella Typhimurium respectively. At the same time, the Swiss mice gave protection reached to 74% and 71% for both organisms when vaccinated and challenged orally, while gave 80% and 82% when vaccinated and challenged intraperitoneally, respectively. The results showed that, the Swiss mice could be used as model in the evaluation of live salmonella vaccines specially when the intraperitoneal route was used in the vaccination and evaluation programs.


Main Subjects