Antimicrobial, Analgesic and Anti-inflammatory Effects of Euphorbia Helioscopia Plant (Al-jejan) Extracts

Document Type : Original Article

Authors

1 Pharmacology Department, Faculty of Veterinary Medicine, Hama University

2 Pharmacology Department, Faculty of Veterinary Medicine, Cairo University

3 Microbiology Department, Faculty of Veterinary Medicine, Cairo University

Abstract

The Antimicrobial, analgesic and anti-inflammatory activities of Euphorbia helioscopia (EH) aqueous and ethanolic extracts were evaluated. The effect of both extracts of EH was tested against some Gram positive, Gram negative and some fungi in vitro. Microtiter plates containing serial dilutions of each extract of EH were inoculated with the tested microorganisms and Microtiter MIC assay was used. The analgesic activity was evaluated against thermally and chemically induced pain in mice, using hot plate and acetic acid-induced writhing methods, respectively. The anti-inflammatory effect was investigated by induction of paw edema and swelling using formalin solution in rats. The results showed that aqueous and ethanolic extracts of EH exhibit effective antibacterial and antifungal activities. Both aqueous and ethanol extracts of EH in doses 250 and 500 mg/kg induced potent analgesic activity, in a dose-dependent manner, using both hot plate and writhing tests. Both extracts of EH induced a marked anti-inflammatory activity as it significantly reduced the paw edema and swelling induced by formalin in paw of rats. In conclusion, aqueous and ethanolic extracts of Euphorbia helioscopia produce antimicrobial, analgesic and anti- inflammatory effects. These results affirm the therapeutic uses of Euphorbia helioscopia in folk medicine for the treatment of bacterial infections, pain and inflammation.

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Veterinary Medical Journal (Giza)
Volume 62, Issue 1
January 2016
Pages 69-75

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