A Canine model of carbon tetrachloride (Ccl4) induced liver cirrhosis: I. Clinical, hematological and biochemical Evaluations

Document Type : Original Article

Authors

1 Depart of Surgery, Anesthesiology and Radiology, Faculty of Vet Med, Cairo University, Egypt

2 Depart of Med Biochemistry and Molecular Biology, Faculty of Mede, Cairo University, Egypt

3 Depart of Pathology, Animal Health Research Institute, Ministry of Agriculture, Egypt

Abstract

The liver is a vital organ of vertebrates and plays a major role in metabolism in addition to other numerous functions in the living body, including regulation of glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. Damage of hepatic cells “Liver cirrhosis” is apotentially life-threatening condition. This could be accredited to a variety of pharmacological agents, viruses, alcohol abuse, autoimmune inflammation and exposure to metabolic metals such as iron, copper and other toxic substances. Carbon tetrachloride (CCl4)is a known highly hepatotoxic agent. This study aimed to assess the degree of liver cirrhosis through clinical and biochemical and hematological analysis after the administration of CCl4 in order to establish a canine model of liver cirrhosis for further research work. Eighteen skeletally mature mongrel dogs received weekly oral administration of CCl4. (ImI/kg 98%) for 16 weeks. Dogs were examined for symptoms of liver cirrhosis and the degree of cirrhosis was recorded through clinical and biochemical and hematological tests. Dogs were of clinical manifestation of liver insufficiency with abnormal hematological and biochemical tests values so we can conclude that, the levels of serum markers of the liver (liver biochemical tests) and other hematological parameters can be taken as a staging indicator of liver cirrhosis.

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Veterinary Medical Journal (Giza)
Volume 62, Issue 1
January 2016
Pages 21-25

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