Modulatory Effect of Origanum Majorana L on Changes Induced: By Bisphenol A in Female ups Rats

El Henafy, Hanan; Ibrahim, Marwa; Abd El Aziz, Samy; Gouda, Eman

doi:10.21608/vmjg.2017.355275

Modulatory Effect of Origanum Majorana L on Changes Induced: By Bisphenol A in Female ups Rats

Document Type : Original Article

Authors

¹ Medical Laboratory Department, Faculty of Applied Medical Sciences, October 6 University

² Biochemistry and Chemistry of Nutrition Department, Faculty of Veterinary Medicine, Cairo University.

10.21608/vmjg.2017.355275

Abstract

Environmental contaminants play an important role in the inheritance of female reproductive dysfunction. Nutraceuticals are able to influence female reproductive function and could be considered a protective agent. The present study investigated the potential effect of the Origanum majorana L (OML) on the oxidative changes induced by Bisphenol A (BPA) in female| offspring. 48 female albino rats were divided into 2 groups. Group I: female rats were given orally 50 mg/kg of BPA / day during gestation and/or lactation periods, and group IJ OML was given orally to dams in a dose of 250 mg /kg daily 3 weeks before BPA administration each as alone or in combination with BPA. At postnatal day 60 (PND 60) serum estradiol (E2): triacylglycerol (TAG), total cholesterol (TC), HDL —cholesterol (HDL-C), LDL- cholesterol (LDL-C), VILDL-cholesterol: (VLDL-C) levels were assayed in female pups. Also, malondialdehyde (MDA) and glutathione (GSH) contents, Superoxide: dismutase (SOD), Catalase (CAT), and Glutathione-s- transferase (GST) activities were estimated in ovarian tissue of pups. BPA exposure resulted in decreased serum E2 and HDL-C levels, ovarian GSH content and SOD; CAT and GST activities. On the other hand BPA increased level of serum TAG,TC, LDL-C, VLDL-C and ovarian MDA content. The observed: antioxidant and hypolipidemic effect of OML co-administration to dams modulated the adverse effects induced by BPA in a time- dependent manner in female pups. In conclusion; the modulatory effect of OML on pup's adverse oxidative changes induced by BPA showed its potential as a protective agent against female reproductive dysfunction.

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