Potential Protective Effect of Vitamin E Against Reproductive Toxicity Induced by Cypermethrin in Male Rats

Document Type : Original Article

Authors

1 Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University

2 Department of Pathology, Faculty of Veterinary Medicine, Cairo University

Abstract

This study was performed to examine the possible protective role of vitamin E against insecticide Cypermethrin (CYM) in male rats. Twenty five sexually mature male rats were randomized into 5 groups: group one was kept as a negative control. In the remaining 4 groups, CYM was orally administered at groups of 15 and 7.5 mg kg (corresponding to 1/10 and 1/20 of LD50) alone and / or in combination with vitamin E for 65 successive days. Blood samples were withdrawn for estimation of testosterone, FSH and LH in the serum. Semen analysis, sex organs weights, antioxidant enzymes superoxide dismutase (SOD); glutathione eroxidase (GPx) and catalase, (CAT) enzyme activities in testicular tissue and histopathological changes in testes were the parameters used in this study. The results showed that concurrent administration of vitamin E with CYM improved the relative weight of testes and increased sperm cell concentration and percentages of sperm motility and viability. There were also significant increases in serum testosterone, FSH and LH levels and in antioxidant enzymes activity in testes. This was associated with amelioration of testicular degenerative changes.ln conclusion vitamin E exerts a protective role against testicular toxicity induced by CYM in male rats.

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Veterinary Medical Journal (Giza)
Volume 63, Issue 1
January 2017
Pages 83-88

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