Uterine and ovarian blood flow in mares treated with silver oxide nanoparticles

Document Type : Original Article

Authors

1 Theriogenology, veterinary medicine, cairo university , giza , egypt

2 theriogenology ,veterinary medicine cairo university

3 theriogenology

4 Animal Reproduction and AI Dept., Veterinary Division, National Research Centre, Dokki, Giza, Egypt.

Abstract

This study aimed to investigate the influence of treatment with silver oxide nanoparticles
intrauterine infusion on ovarian and uterine blood flow, cortisol, estradiol (E2) and interlukine-10 (IL-10). Mares (N=8), diagnosed positive to endometritis, were examined by Doppler ultrasonography. Blood samples were collected prior to each ultrasound exam.. Blood sera were used to assay cortisol, E2, and IL-10. The uterine and ovarian arteries’ time average mean velocity (TAMV) and blood flow volume(BFV) were determined. Mares were infused intrauterine with 50 mg/kg body weight of silver oxide nanoparticles on Day 7(from ovulation ) and another dose on Day 14 from ovulation . On day 21 from ovulation , there were significant decreases in BFV and TAMV values of the uterine (P< 0.001; P< 0.05, respectively) and ovarian arteries (P< 0.0001). A non-significant change in the cortisol and IL-10 was noticed throughout the treatment. In conclusion, silver oxide nanoparticles modulated uterine and ovarian blood flow in endometritis suffered mares on day 21 post-treatment.

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