Augmentation of carpal arthrodesis using mesenchymal stem cells derived microvesicles and cancellous bone graft in dogs

Document Type : Original Article

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Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Abstract

A novel application of mesenchymal stem cell-derived microvesicles (MSC-derived MVs) with arthrodesis in dogs is described, and radiographic osseous union, lameness score, histological findings, and complications following surgery are assessed. This study compared the procedure type in 20 cases of pan carpal arthrodesis in dogs treated with (MSCs derived MVs) and cancellous bone autografts (mixed group) and cancellous bone autografts alone (BG group). Radiographs were compared at 4, 8 and 12 weeks after surgery to find that the (MSCs derived MVs) group had greater scores than others in terms of radiographic osseous union and histopathological evidence of bone formation. When compared to the (MSCs derived MVs) group, the BG group had considerably more serious problems that necessitated re-operation for implant removal or treatment of a deep infection. Overall, MSC-derived microvesicles (MSC-derived MVs) can be used to complement arthrodesis in dogs without causing considerable morbidity

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